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Artificial Insemination With Donor Sperm May Be A Good Option For Patients Who Have Not Had Success Using IVF With ICSI

October 2003
American Society for Reproductive Medicine

Success using IVF with ICSI is dependent on both egg-related factors and sperm-related factors. For couples trying to conceive who have complex infertility disorders, multiple cycles of IVF-ICSI might be attempted with accompanying high economic and emotional costs and great uncertainty of outcome. Artificial insemination with donor sperm (AID) may be a good alternative treatment for infertile couples who have not had success using ICSI and who are willing to forgo the father's genetic connection to his child.

Doctors at the Oregon Health and Science University reviewed the records of 19 couples who failed to achieve pregnancy in a total of 32 IVF-ICSI cases from 1994 through 2001 and then elected to try AID. As a group, 61 AID cycles were completed, with 16 couples conceiving within seven cycles of donor insemination. Seventeen pregnancies resulted, with 15 live births. The average number of inseminations done to achieve pregnancy was 3.2 and the pregnancy rate per cycle was 27.9%.

These results compare well with the clinic's overall AID program in which the pregnancy rate per cycle ranged from 8.4% to 19.4% in the years 1994 through 2001. While the researchers noted that it is unlikely that pregnancy rates as high as those they observed in this small group would persist in further clinical experience, the outcomes for couples included in this small study indicate that AID is a reasonable and effective option, even for couples with a poor prognosis, who fail to conceive using IVF with ICSI.

(Gorrill et al, Pregnancy outcomes using donor sperm insemination after failed in vitro fertilization with intracytoplasmic sperm injection cycles in couples with complex infertility disorders, Fertility and Sterility, Vol.80, No.4, October 2003.)

The American Society for Reproductive Medicine, founded in 1944, is an organization of close to 9,000 physicians, researchers, nurses, technicians, and other professionals dedicated to advancing knowledge and expertise in reproductive biology. Affiliated societies include the Society for Assisted Reproductive Technology, The Society for Male Reproduction and Urology, the Society for Reproductive Endocrinology and Infertility, and the Society of Reproductive Surgeons.

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