PCOS - Metformin Use in Pregnancy
By Samuel Thatcher, MD, Ph.D.

Q. I just found out that I am pregnant. I've been on glucophage for 2 months. I would rarely have periods, so I expected that the glucophage would help with periods. I was very surprised to find out that I had conceived so soon. My question is do you think it is safe to stay on the medication while pregnant?

A. There is very limited information on this. One study has shown a decrease in the rate of miscarriage in a relatively small group of patients. Another study also reported no problem when used during pregnancy. In the future, metformin may be widely used in pregnancy, but its use can not be universally recommended at present. We just do not know the risks. Hopefully this issue will be cleared up in the near future. A decision should be made in conjunction with advice from your obstetrician.